Article No
AM2250b-ev
Specifications
| MW | 58282 |
| Accession Number | Q96RK4 |
| Application | WB |
| Article No | AM2250b-ev |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 1292CT845.130.218 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | BBS4 Antibody (Center) |
| Recommended Dilution | 1:250 |
| Supplier | Abgent |
| Entrez Gene ID | 585 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Isotype | IgG1 |
| Keywords | Crown Antibodies;Primary Antibodies;Metabolism;Neuroscience |
| Notes | The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. |
| Alias Names | Bardet-Biedl syndrome 4 protein, BBS4 |
| Product Type | Antibodies Primary |
| Research area | Metabolism |
| Size | 80 µl |
| Source / Host | mouse |
| Species Reactivity | human, mouse, rat |
| Substrate / Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Technical Specifications | This BBS4 antibody is generated from a mice immunized with a recombinant protein between 1-240 amino acids from human BBS4. |
| Product Page Updated | 2023-11-23T14:38:54.086Z |
