Article No
MON2070
Mouse anti-CD105, clone MEM-226
Mouse anti-CD105, clone MEM-226
Antibodies Primary
Specifications
| Additional Information | CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
| Application | FC, IP, WB |
| Article No | MON2070 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | MEM-226 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Mouse anti-CD105, clone MEM-226 |
| Supplier | SANBIO bv/Monosan |
| Format | - |
| Immunogen | Recombinant Vaccinia virus containing the human CD105 cDNA. |
| Isotype | IgG2a |
| Notes | CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
| Product Type | Antibodies Primary |
| Protocol | FC , IP, WB |
| Shipping Information | blue ice |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | rat, human |
| Storage | 2-8°C |
| Substrate / Buffer | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Product Page Updated | 2024-01-12T18:37:31.725Z |
