Article No
M044-3
Application | IHC, WB |
Article No | M044-3 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 2F1 |
Clone Type | monoclonal |
Concentration | 1 mg/mL |
Conjugation | Unconjugated |
Description | Anti-XIAP (MIHA/ILP-a) (Human) mAb |
Supplier | MBL |
Immunogen | Full-length recombinant human XIAP protein |
Isotype | IgG1 |
Notes | Caspase, related to ICE and to CED- 3, play central roles as effectors of apoptosis. Ablation of caspase activity is attained by p35 from baculovirus and CrmA from cowpox, which appear to be suicide inactivators, strongly inhibiting caspase activity. Overexpression of there caspase inhibitors in insect, nematoda and mammalian cells results in resistance to apoptotic stimuli, demonstrating that components of the apoptotic pathway are highly conserved throughout evolution, and leading to the speculation that mammalian functional equivalents of these protease inhibitors may exist. The inhibitor of apoptosis proteins (IAPs) are a family of anti-apoptotic proteins that are conserved across species. Four IAPs have been identified in mammal; NAIP, cIAP1/HIAP2/hMIHB, cIAP2/HIAP1/hMIHC, XIAP/hILP. A prototype of the human IAPs is the XIAP, with a 1.5 kb coding region corresponding to a 55 kDa protein. XIAP can directly inhibit two members of the cell death protease family, caspase-3 and -7. |
Product Type | Antibodies Primary |
Research area | Cell Death |
Shipping Information | 4°C |
Size | 100 µg |
Source / Host | mouse |
Species Reactivity | human, mouse, rat |
Stability | 1 year |
Storage | -20°C |
Substrate / Buffer | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
Technical Specifications | Caspase, related to ICE and to CED- 3, play central roles as effectors of apoptosis. Ablation of caspase activity is attained by p35 from baculovirus and CrmA from cowpox, which appear to be suicide inactivators, strongly inhibiting caspase activity. Overexpression of there caspase inhibitors in insect, nematoda and mammalian cells results in resistance to apoptotic stimuli, demonstrating that components of the apoptotic pathway are highly conserved throughout evolution, and leading to the speculation that mammalian functional equivalents of these protease inhibitors may exist. The inhibitor of apoptosis proteins (IAPs) are a family of anti-apoptotic proteins that are conserved across species. Four IAPs have been identified in mammal; NAIP, cIAP1/HIAP2/hMIHB, cIAP2/HIAP1/hMIHC, XIAP/hILP. A prototype of the human IAPs is the XIAP, with a 1.5 kb coding region corresponding to a 55 kDa protein. XIAP can directly inhibit two members of the cell death protease family, caspase-3 and -7. |
Product Page Updated | 2023-12-29T16:20:16.638Z |