Article No
LS-C188390-0.2
MMP9 / Gelatinase B
Gelatinase B antibody LS-C188390 is an unconjugated mouse monoclonal antibody to human Gelatinase B (MMP9) (N-Terminus). Validated for IHC and WB.
Antibodies Primary
Specifications
| NCBI Number | 4318 |
| Application | IHC, WB |
| Article No | LS-C188390-0.2 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | 4A3 |
| Clone Type | monoclonal |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Description | Gelatinase B antibody LS-C188390 is an unconjugated mouse monoclonal antibody to human Gelatinase B (MMP9) (N-Terminus). Validated for IHC and WB. |
| Recommended Dilution | IHC-P (1:25 - 1:100) |
| Supplier | LifeSpan Biosciences |
| Entrez Gene ID | 4318 |
| Gene Symbol | MMP9 |
| Immunogen | Ovalbumin conjugated synthetic peptide corresponding to a region within the N-Terminus of human MMP-9. |
| Isotype | IgG1 |
| Notes | Gelatinase B antibody LS-C188390 is an unconjugated mouse monoclonal antibody to human Gelatinase B (MMP9) (N-Terminus). Validated for IHC and WB. |
| Alias Names | MMP9, 92kd gelatinase, 92 kDa gelatinase, Matrix metalloproteinase-9, MMP-9, CLG4B, Gelatinase B, GELB, Macrophage gelatinase, MANDP2 |
| Product Type | Antibodies Primary |
| Protocol | IHC, IHC-P (1:25 - 1:100), WB |
| Purification | Protein G Purified |
| Shipping Information | RT |
| Size | 0.2 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | -20°C |
| Substrate / Buffer | PBS, 0.09% Sodium Azide |
| Technical Specifications | Recognizes the active form of human matrix metalloproteinase 9 (MMP-9). The MMPs are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMPs are synthesized as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-9 is a gelatinase, cleaving type IV collagen and gelatin. The gelatinases have an additional gelatin-binding domain inserted in the catalytic domain. MMP-9, alongside other MMPs, plays a role in normal tissue remodeling such as embryonic development, ovulation, mammary gland involution and wound healing. It is important in the early stages of tumor invasion as it degrades the type IV collagen in the basement membrane. The antibody recognizes only the active form of MMP-9. It does not react with the MMP-9 proenzyme or the active or proenzyme forms of MMP-2. |
| Product Page Updated | 2024-04-12T06:35:05.844Z |
