Article No
GTX80264
CD8 alpha
The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
Antibodies Primary
Specifications
| Application | FC |
| Article No | GTX80264 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 53-6.7 |
| Clone Type | monoclonal |
| Concentration | 0.5 mg/ml |
| Conjugation | FITC |
| Description | The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites. |
| Supplier | GeneTex |
| Entrez Gene ID | 12525 |
| Gene Symbol | Cd8a |
| Immunogen | Mouse spleen cells |
| Isotype | IgG2a |
| Product Type | Antibodies Primary |
| Purification | Affinity Purified |
| Size | 100µg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Storage | 4°C |
| UniProt Number | P01731 |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
