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3-Deoxyaphidicolin

Chemicals & Biochemicals

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Article No

BVT-0451-C250

Size

250 ug

Shipping Information

Article No

BVT-0451-C250

Size

250 ug

Specifications

CAS No	85483-00-7
MW	322.5
Article No	BVT-0451-C250
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	3-Deoxyaphidicolin
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Chemical. CAS: 85483-00-7. Formula: C20H34O3. MW: 322.5. Isolated from Phoma sp. BS 7210. Inhibitor of eukaryotic DNA synthesis. Mycotoxin. Phytotoxic and cytotoxic agent. Specific inhibitor of DNA polymerase alpha.\|Inhibitor of eukaryotic DNA synthesis. Mycotoxin. Phytotoxic and cytotoxic agent. Specific inhibitor of DNA polymerase alpha.
Molecular Formula	C20H34O3
Alias Names	(+)-3-Deoxyaphidicolin
Product Type	Chemicals & Biochemicals
Purity	>98%
Research area	Cell Death
Shipping Information	RT
Size	250 ug
Solubility	Soluble in DMSO (50 mg/ml), methanol (10 mg/ml) or 100% ethanol; insoluble in water.
Stability	Stable for at least 1 year after receipt when stored at +4°C.
Storage	4°C
Technical Specifications	Chemical. CAS: 85483-00-7. Formula: C20H34O3. MW: 322.5. Isolated from Phoma sp. BS 7210. Inhibitor of eukaryotic DNA synthesis. Mycotoxin. Phytotoxic and cytotoxic agent. Specific inhibitor of DNA polymerase alpha.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase alpha, 3-deoxyaphidicolin and aphidicolion-17-monoacetate: T. Haraguchi, et al.; Nucleic Acids Res. 11, 1197 (1983) | 3-Deoxyaphidicolin and aphidicolin analogs as phytotoxins from Phoma betae: A. Ichihara, et al.; Agr. Biol. Chem. 48, 1687 (1984) | Phytotoxicity of the new metabolites produced by Phoma betae, the cause of Phoma root rot and leaf spot in sugar beet (Beta vulgaris L.): R. Sakai, et al.; Nippon Shokubutsu Byori Gakkaiho 51, 219 (1985) | An efficient conversion of 1-abietic acid to (+)-3-deoxyaphidicolin: H. Koyama, et al.; Tetrahedron Lett. 26, 2685 (1985) | Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA polymerase alpha in vitro: S. Hiranuma, et al.; Chem. & Pharm. Bull. 35, 1641 (1987) | Structure-activity relationships for the inhibition of DNA polymerase alpha by aphidicolin derivatives: G. Prasad, et al.; Nucleic Acids Res. 17, 6339 (1989) | Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha: heterologous expression of four biosynthetic genes in Aspergillus oryzae: R. Fujii, et al.; Biosci. Biotech. Bioch. 75, 1813 (2011)

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