Article No
ASB-UVHAEY-0.5
Rat Anti-Mouse CD11b-LE/AF
Rat Anti-Mouse CD11b-LE/AF
Antibodies Primary
Specifications
| NCBI Number | 16409, 3684, 714832, 101004087, 100351865 |
| Application | FC, IHC, ICC, IP, Block |
| Article No | ASB-UVHAEY-0.5 |
| Biosite Brand | Biosite |
| Country Availability | all |
| Clone | M1/70 |
| Clone Type | monoclonal |
| Concentration | 0.5 mg/mL |
| Conjugation | LEAF |
| Description | Rat Anti-Mouse CD11b-LE/AF |
| Supplier | Nordic Biosite |
| Format | Liquid |
| Immunogen | C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes |
| Isotype | IgG2b |
| Notes | CD11b, the integrin alphaM subunit, combines with CD18, the integrin beta2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells. |
| Alias Names | Integrin αM, Mac-1α, Mac-1, Mo1, CR3, C3biR |
| Previous Article No | ASB-AS6KAT-0.5, ASB-156114, ASB-UVHAEY-0.5 |
| Product Type | Antibodies Primary |
| Shipping Information | Dry Ice |
| Size | 0.5 mg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Storage | -20°C |
| Substrate / Buffer | Phosphate buffered saline, pH 7.4 |
| Swiss-Prot No | P05555, P11215 |
| Product Page Updated | 2024-01-11T10:51:07.446Z |
| Volume | 1.0 mL |
