Article No
ASB-AZDOOL-0.5
NCBI Number | 12525 |
Application | FC, IHC, ICC |
Article No | ASB-AZDOOL-0.5 |
Biosite Brand | Biosite |
Country Availability | all |
Clone | 53-6.7 |
Clone Type | monoclonal |
Concentration | 0.5 mg/mL |
Conjugation | FITC |
Description | Rat Anti-Mouse CD8α-FITC |
Supplier | Nordic Biosite |
Format | Liquid |
Immunogen | Spleen cells or thymocyte membranes |
Isotype | IgG2a |
Notes | In the mouse, CD8 exists in two forms - (i) a CD8 heterodimer composed of an alpha chain (CD8 alpha) and a beta chain (CD8 beta); and (ii) a homodimer of two alpha chains. The heterodimer is found on the surface of essentially all thymocytes and the "suppressor/cytotoxic" subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8 alpha without CD8 beta. It has been suggested that CD8+ beta- T cells mature extrathymically, while development of the CD8 alpha+ beta+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8 alpha+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2. |
Alias Names | Ly-2, Lyt-2, Ly-35, Ly-B, T8 |
Previous Article No | ASB-6GA82D-0.5, ASB-155002, ASB-AZDOOL-0.5 |
Product Type | Antibodies Primary |
Shipping Information | Ambient Temperature |
Size | 0.5 mg |
Source / Host | rat |
Species Reactivity | mouse |
Storage | 2-8°C |
Substrate / Buffer | Phosphate buffered saline containing < 0.1% sodium azide |
Swiss-Prot No | P01731 |
Product Page Updated | 2024-01-11T10:51:07.446Z |
Volume | 1.0 mL |