Article No
AMB-2RIEUD-100
CDC2 Primary Antibody
CDC2 Primary Antibody
Antibodies Primary
Specifications
| MW | 34kDa |
| Application | WB, ELISA |
| Article No | AMB-2RIEUD-100 |
| Biosite Brand | Biosite mAb |
| Country Availability | all |
| Clone | 8C5A6 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | CDC2 Primary Antibody |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 983 |
| Format | Ascitic fluid containing 0.03% sodium azide. |
| Immunogen | Purified recombinant fragment of CDC2 expressed in E. Coli. |
| Isotype | IgG1 |
| Notes | The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration. |
| Alias Names | CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; CDK1 |
| Previous Article No | AMB-8477 |
| Product Type | Antibodies Primary |
| Protocol | ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000 |
| Size | 100µl |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C -20°C for long term storage |
| Substrate / Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Technical Specifications | ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000 |
| Product Page Updated | 2024-01-25T14:27:22.065Z |
