Article No
AMB-EOMNH6-100
FES Primary Antibody
FES Primary Antibody
Antibodies Primary
Specifications
| Application | WB, ELISA |
| Article No | AMB-EOMNH6-100 |
| Biosite Brand | Biosite mAb |
| Country Availability | all |
| Clone | 5A11G5 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | FES Primary Antibody |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 2242 |
| Format | Ascitic fluid containing 0.03% sodium azide. |
| Immunogen | Purified recombinant fragment of FES expressed in E. Coli. |
| Isotype | IgG1 |
| Notes | FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer. |
| Alias Names | FPS |
| Previous Article No | AMB-8207 |
| Product Type | Antibodies Primary |
| Protocol | ELISA: 1/10000; WB: 1/500 - 1/2000 |
| Size | 100µl |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C -20°C for long term storage |
| Substrate / Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Technical Specifications | ELISA: 1/10000; WB: 1/500 - 1/2000 |
| Product Page Updated | 2024-01-25T14:27:22.065Z |
