Article No
AG-CN2-0475-M001
Specifications
| CAS No | 13289-18-4 |
| MW | 724.8 |
| Article No | AG-CN2-0475-M001 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | Hellebrin |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Notes | Chemical. CAS: 13289-18-4. Formula: C36H52O15. MW: 724.8. Isolated from Helleborus purpurascens. Highly potent Na+/K+-ATPase inhibitor, blocking the active efflux of Na+ and reuptake of K+. Water soluble cardiotonic glycoside from the class of bufadienolides (with 2-pyrone ring). Inhibits cancer cell growth in vitro. Shown to induce caspase-dependent apoptosis, reducing MDR resistance and the rate of mitochondrial oxidative phosphorylation in cancer cells. Inotropic by increasing the intracellular Ca2+ concentration. Immunosuppressive and anti-inflammatory agent that inhibits allogeneic T cell activation with much higher potency than cortisol or cyclosporin A.|Highly potent Na+/K+-ATPase inhibitor, blocking the active efflux of Na+ and reuptake of K+. Water soluble cardiotonic glycoside from the class of bufadienolides (with 2-pyrone ring). Inhibits cancer cell growth in vitro. Shown to induce caspase-dependent apoptosis, reducing MDR resistance and the rate of mitochondrial oxidative phosphorylation in cancer cells. Inotropic by increasing the intracellular Ca2+ concentration. Immunosuppressive and anti-inflammatory agent that inhibits allogeneic T cell activation with much higher potency than cortisol or cyclosporin A. Anti-seizure activity in pentylenetetrazole (PTZ)-induced epileptical seizures. |
| Molecular Formula | C36H52O15 |
| Alias Names | 3beta-(O4-beta-D-Glucopyranosyl-alpha-L-rhamnopyranosyloxy)-5,14-dihydroxy-19-oxo-5beta,14-beta-bufa-20,22-dienolide; NSC93134 |
| Product Type | Chemicals & Biochemicals |
| Purity | >99% |
| Research area | Cell Death |
| Shipping Information | RT |
| Size | 1 mg |
| Solubility | Soluble in water (~4mg/ml). |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Technical Specifications | Chemical. CAS: 13289-18-4. Formula: C36H52O15. MW: 724.8. Isolated from Helleborus purpurascens. Highly potent Na+/K+-ATPase inhibitor, blocking the active efflux of Na+ and reuptake of K+. Water soluble cardiotonic glycoside from the class of bufadienolides (with 2-pyrone ring). Inhibits cancer cell growth in vitro. Shown to induce caspase-dependent apoptosis, reducing MDR resistance and the rate of mitochondrial oxidative phosphorylation in cancer cells. Inotropic by increasing the intracellular Ca2+ concentration. Immunosuppressive and anti-inflammatory agent that inhibits allogeneic T cell activation with much higher potency than cortisol or cyclosporin A. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
