Article No
AG-CN2-0058-C100
Okadaic acid . ammonium salt (high purity)
Okadaic acid . ammonium salt (high purity)
Chemicals & Biochemicals
Specifications
| CAS No | 175522-42-6 |
| MW | 804.0 . 18.0 |
| Additional Information | Salt form of okadaic acid (Prod. No. AG-CN2-0056) with slightly greater stability than the free acid after it is put into stock solution (in organic solvents). |
| Article No | AG-CN2-0058-C100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | Okadaic acid . ammonium salt (high purity) |
| Supplier | Adipogen Life Sciences |
| Additional Information | Salt form of okadaic acid (Prod. No. AG-CN2-0056) with slightly greater stability than the free acid after it is put into stock solution (in organic solvents). |
| Format | Powder |
| Notes | Chemical. CAS: 175522-42-6. Formula: C44H67O13 . NH4. MW: 804.0 . 18.0. Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization.|Non-phorbol type tumor promoter [1]. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C [2, 6, 7, 18]. Stimulates intracellular protein phosphorylation [3]. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase [4, 5]. Mimics the effects of insulin [7]. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes [14, 19]. Enhances transmitter release at neuromuscular junctions [8]. Apoptosis inhibitor [9, 11, 12]. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells [10]. Neurotoxic [12, 16]. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling [13, 15, 17, 18]. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization [20]. |
| Molecular Formula | C44H67O13 . NH4 |
| Alias Names | Halochondrine A; CCRIS 3329; HSDB 7243; 9,10-Deepithio-9,10-didehydroacanthifolicin |
| Product Type | Chemicals & Biochemicals |
| Protocol | Salt form of okadaic acid (Prod. No. AG-CN2-0056) with slightly greater stability than the free acid after it is put into stock solution (in organic solvents). |
| Purity | >98% |
| Research area | Metabolism |
| Shipping Information | RT |
| Size | 100 ug |
| Solubility | Soluble in DMSO, ethanol, methanol, acetone, ethyl acetate or distilled water. Dissolve first in organic solvent before diluting in water. |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Technical Specifications | Chemical. CAS: 175522-42-6. Formula: C44H67O13 . NH4. MW: 804.0 . 18.0. Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
