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Resveratrol

Chemicals & Biochemicals

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Article No

AG-CN2-0033-M500

Size

500 mg

Shipping Information

Article No

AG-CN2-0033-M500

Size

500 mg

Specifications

CAS No	501-36-0
MW	228.2
Article No	AG-CN2-0033-M500
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	Resveratrol
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Chemical. CAS: 501-36-0. Formula: C14H12O3. MW: 228.2. Isolated from Polygonum cuspidatum. Potent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 (COX-1). Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2 phase. Anticancer and antiproliferative compound. Apoptosis inducer. Protein kinase D inhibitor. Does not inhibit PKC. Autophagy inducer. Potent SIRT1 (sirtuin 1) activator. Neuroprotective. Adipogenesis inhibitor. PGC-1alpha activator. Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity. Cardioprotective. Anti-diabetic. Senescence modulator. Extends lifespan. Inhibitor of NLRP3 inflammasome activation.\|Potent phenolic antioxidant found in grapes and red wine [1, 19]. Eicosanoid synthesis and platelet aggregation inhibitor [2]. Estrogen receptor agonist [3]. Chemopreventive [4, 15]. Specific inhibitor of cyclooxygenase-1 (COX-1) [4]. Anti-inflammatory [4, 21]. Ribonucleotide reductase and DNA synthesis [5]. Arrests cell cycle at S/G2 phase [6, 23]. Anticancer and antiproliferative compound [7, 16]. Apoptosis inducer [8, 23]. Protein kinase D inhibitor. Does not inhibit PKC [9]. Autophagy inducer [10, 23]. Potent SIRT1 (sirtuin 1) activator [11, 22]. Neuroprotective [12, 18]. Adipogenesis inhibitor [13]. PGC-1alpha activator [14]. Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity [17]. Cardioprotective [19, 21]. Anti-diabetic [20]. Senescence modulator. Extends lifespan [22]. Inhibitor of NLRP3 inflammasome activation [24].
Molecular Formula	C14H12O3
Alias Names	trans-3,4’,5-Trihydroxystilbene; trans-Resveratrol; (E)-Resveratrol; 3,4’,5-Stilbenetriol
Product Type	Chemicals & Biochemicals
Purity	>98%
Research area	Cell Death
Shipping Information	RT
Size	500 mg
Solubility	Soluble in DMSO, ethanol or DMF. Slightly soluble in water or PBS.
Stability	Stable for at least 2 years after receipt when stored at -20°C.
Storage	-20°C, 4°C
Technical Specifications	Chemical. CAS: 501-36-0. Formula: C14H12O3. MW: 228.2. Isolated from Polygonum cuspidatum. Potent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 (COX-1). Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2 phase. Anticancer and antiproliferative compound. Apoptosis inducer. Protein kinase D inhibitor. Does not inhibit PKC. Autophagy inducer. Potent SIRT1 (sirtuin 1) activator. Neuroprotective. Adipogenesis inhibitor. PGC-1alpha activator. Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity. Cardioprotective. Anti-diabetic. Senescence modulator. Extends lifespan. Inhibitor of NLRP3 inflammasome activation.
Product Page Updated	2024-02-01T08:25:01.492Z

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MSDS

References

Antioxidant activity of resveratrol in red wine: N.J. Miller & C. Rice-Evans; Clin. Chem. 41, 1789 (1995) | The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease: C.R. Pace-Asciak, et al.; Clin. Chem. Acta 235, 207 (1995) | Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor: B.D. Gehm, et al.; PNAS 94, 14138 (1997) | Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997) | Resveratrol, a remarkable inhibitor of ribonucleotide reductase: M. Fontecave, et al.; FEBS Lett. 421, 277 (1998) | Resveratrol arrests the cell division cycle at S/G2 phase transition: F.D. Ragione, et al.; BBRC 250, 53 (1998) | Antiproliferative effect of synthetic resveratrol on human breast epithelial cells: O.P. Mgbonyebi, et al.; Int. J. Oncol. 12, 865 (1998) | Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells: J. Dörrie, et al.; Cancer Res. 61, 4731 (2001) | Inhibition of protein kinase D by resveratrol: R.S. Haworth & M. Avkiran; Biochem. Pharmacol. 62, 1647 (2001) | Resveratrol-induced autophagocytosis in ovarian cancer cells: A.W. Jr. Opipari, et al.; Cancer Res. 64, 696 (2004) | Mechanism of Human SIRT1 Activation by Resveratrol: MT. Borra, et al.; J. Biol. Chem. 280, 17187 (2005) | Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?: P. Saiko, et al.; Mutat. Res. 658, 68 (2008) | Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes: S. Rayalam, et al.; Phytother. Res. 22, 1367 (2008) | Resveratrol exerts pharmacological preconditioning by activating PGC-1alpha: L. Tan, et al.; Med. Hypotheses 71, 664 (2008) | Resveratrol and chemoprevention: S.K. Goswami & D.K. Das; Cancer Lett. 284, 1 (2009) (Review) | Resveratrol: Biological and pharmaceutical properties as anticancer molecule: T.C. Hsieh & J.M. Wu; Biofactors 36, 360 (2010) (Review) | Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer: A. Slusarz, et al.; Cancer Res. 70, 3382 (2010) | Neuroprotective properties of resveratrol in different neurodegenerative disorders: D. Albani, et al.; Biofactors 36, 370 (2010) (Review) | Resveratrol: a cardioprotective substance: J.M. Wu & T.C. Hsieh; Ann. N. Y. Acad. Sci. 1215, 16 (2011) (Review) | Anti-diabetic effects of resveratrol: T. Szkudelski & K. Szkudelska; Ann. N. Y. Acad. Sci. 1215, 34 (2011) (Review) | Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease: A. Csiszar; Ann. N. Y. Acad. Sci. 1215, 117 (2011) (Review) | Resveratrol and life extension: B. Agarwal & J.A. Baur; Ann. N. Y. Acad. Sci. 1215, 138 (2011) (Review) | Resveratrol, a phytochemical inducer of multiple cell death pathways: apoptosis, autophagy and mitotic catastrophe: D. Delmas, et al.; Curr. Med. Chem. 18, 1100 (2011) (Review) | Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy: Y.P. Chang, et al.; J. Cell Physiol. 230, 1567 (2015)

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