Article No
AFC-CMH12N-100
Anti-Hu CD184 PE-Cy™7
Anti-Hu CD184 PE-Cy™7
Antibodies Primary
Specifications
| Application | FC |
| Article No | AFC-CMH12N-100 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | 12G5 |
| Clone Type | monoclonal |
| Conjugation | PE/Cy7 |
| Description | Anti-Hu CD184 PE-Cy™7 |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 7852 |
| Format | PE-Cy™7 |
| Immunogen | CP-MAC-infected Sup-T1 cells |
| Isotype | IgG2a k |
| Notes | CD184, also known as CXCR4 or fusin, is a receptor for the C-X-C chemokine SDF-1. It is expressed mainly in hematopoietic cells, vascular endothelium, and neural tissue. CD184 is a G-protein coupled receptor containing extracellular N-terminal, seven transmembrane domains and intracellular C-terminal domain. It transduces signal by increasing the intracellular calcium level. CD184 plays an essential role in vascularization of the gastrointestinal tract, and is involved in cerebellar development and in hematopoiesis. It is also a coreceptor (with CD4) for HIV-1 X4 virus and a primary receptor for some HIV-2 isolates. |
| Alias Names | CXCR4, LAP3, LCR1, HM89, fusin, SDF1R |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. |
| Purification | Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-cyanine 7 (PE-Cy™7) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Size | 100 tests |
| Source / Host | mouse |
| Species Reactivity | human, monkey |
| Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
| Substrate / Buffer | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody 12G5 recognizes an extracellular epitope of CD184, a 45 kDa G-protein-linked CXC chemokine receptor widely expressed on blood and tissue cells. |
| UniProt Number | P61073 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
