Article No
AFC-VIH1UG-0.1
Specifications
| Application | FC |
| Article No | AFC-VIH1UG-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | ITEM-4 |
| Clone Type | monoclonal |
| Concentration | 0.1 mg/ml |
| Conjugation | PE |
| Description | Anti-Hu CD266 PE |
| Recommended Dilution | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 51330 |
| Format | PE |
| Immunogen | human CD266-transfected P815 cells |
| Isotype | IgG2b |
| Keywords | Apoptosis (Rodent), CD and Related Antigens & MHC (Rodent), Apoptosis (Human), CD and Related Antigens (Human) |
| Notes | CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential. |
| Alias Names | TWEAKR, FN14, TNFRSF12A |
| Previous Article No | AFC-5326-2, AFC-VIH1UG-0.1 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: Recommended dilution: 2-4 μg/ml. |
| Purification | Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Research area | Cell Death |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | mouse, human |
| Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
| Substrate / Buffer | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody ITEM-4 recognizes an extracellular epitope of CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis. |
| UniProt Number | Q9NP84 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
