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Anti-Cytokeratin 18 FITC

Antibodies Primary

Make a customized order

Article No

AFC-FIYJY5-0.1

Application

Species Reactivity

human

Size

0.1 mg

Clone

DC-10

Source / Host

mouse

Article No

AFC-FIYJY5-0.1

Application

Species Reactivity

human

Size

0.1 mg

Clone

DC-10

Source / Host

mouse

Specifications
Suggested protocols
References

Specifications

Application	FC
Article No	AFC-FIYJY5-0.1
Biosite Brand	Biosite Flow
Country Availability	all
Clone	DC-10
Clone Type	monoclonal
Concentration	0.1 mg/ml
Conjugation	FITC
Description	Anti-Cytokeratin 18 FITC
Recommended Dilution	The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.
Supplier	Nordic Biosite
Entrez Gene ID	3875
Format	FITC
Immunogen	Human breast carcinoma cell line PMC-42.
Isotype	IgG1
Keywords	Cytoskeleton: Intermediate Filaments (Human), Cytoskeleton: Intermediate Filaments
Notes	Cytokeratins are a subfamily of intermediate filaments and are characterized by remarkable biochemical diversity. They are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families. Cytokeratin 18 belongs to type I family (acidic cytokeratins).
Alias Names	K18, CK18, CYK18, KRT18
Previous Article No	AFC-4920-2, AFC-FIYJY5-0.1
Product Type	Antibodies Primary
Protocol	Flow cytometry: Recommended dilution: 1-5 μg/ml. Intracellular staining.
Purification	Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Research area	Cell Proliferation
Size	0.1 mg
Source / Host	mouse
Species Reactivity	human
Storage	Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Substrate / Buffer	Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Technical Specifications	The mouse monoclonal antibody DC-10 reacts with cytokeratin 18 (45 kDa). Cytokeratins are members of intermediate filaments subfamily of intracellular proteins, represented in epithelial tissues.
UniProt Number	P05783
Product Page Updated	2024-01-03T12:18:20.318Z

Suggested protocols

Flow Cytometry

References

*Lauerova L, Kovarik J, Bartek J, Rejthar A, Vojtesek B: Novel monoclonal antibodies defining epitope of human cytokeratin 18 molecule. Hybridoma. 1988 Oct;7(5):495-504., URL: https://www.ncbi.nlm.nih.gov/pubmed/2461901?dopt=A,*Kovarik J, Rejthar A, Lauerova L, Vojtesek B, Bartkova J: Monoclonal antibodies against individual cytokeratins in the detection of metastatic spread. Int J Cancer Suppl. 1988;3:50-5., URL: https://www.ncbi.nlm.nih.gov/pubmed/2463228?dopt=A,*Vojtesek B, Staskova Z, Nenutil R, Lauerova L, Kovarik J, Rejthar A, Bartkova J, Bartek J: Monoclonal antibodies recognizing different epitopes of cytokeratin No.18. Folia Biol (Praha). 1989;35(6):373-82. , URL: https://www.ncbi.nlm.nih.gov/pubmed/2483834?dopt=A,,*Čáp J, Čermáň J, Němeček S, Marková M, Haná V, Frysák Z: The influence of treatment with somatostatin analogues on morphology, proliferative and apoptotic activity in GH-secreting pituitary adenomas. J Clin Neurosci. 2003 Jul;10(4):444-8. , URL: https://www.ncbi.nlm.nih.gov/pubmed/12852883?dopt=,*Kovařík J. et al., J. Tumor Marker Oncol. 5, 219 (1990)., URL: ,*Taylor-Papadimitriou J, Stampfer M, Bártek J, Lewis A, Boshell M, Lane EB, Leigh IM: Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium. J Cell Sci. 1989 Nov;94 ( Pt 3):403-13., URL: https://www.ncbi.nlm.nih.gov/pubmed/2483723?dopt=A,,

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