Antibodies Primary

CD19

NEW
Mouse Monoclonal to CD19

Article No

AFC-4875-2

Application

FC, IP

Species Reactivity

human

Size

0.1 mg

Clone

LT19

Suggested protocols

Specifications

Application FC, IP
Article No AFC-4875-2
BioSite Brand BioSite Flow
Clone LT19
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Biotin
Description Mouse Monoclonal to CD19
Recommended Dilution The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Supplier BioSite Flow
Immunogen Daudi human Burkitt lymphoma cell line
Isotype IgG1
Keywords CD and Related Antigens (Human)
Notes CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Product Type Antibodies Primary
Research Area Immunology
Size 0.1 mg
Species Reactivity human
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The antibody LT19 reacts with CD19 (B4), a 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells._x000D_ <br>_x000D_ <b>HLDA 10</b>
Product Page Updated 2018-07-27T09:12:01.609Z

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