Article No
AFC-FKZT11-100
Specifications
| Application | FC |
| Article No | AFC-FKZT11-100 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | T21/8 |
| Clone Type | monoclonal |
| Conjugation | APC |
| Description | Anti-Hu CD195 APC |
| Recommended Dilution | The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 1234 |
| Format | APC |
| Immunogen | CCR5 peptide (Met1-Lys22) KLH conjugate |
| Isotype | IgG1 k |
| Keywords | Cytokine Signaling (Human), CD and Related Antigens (Human) |
| Notes | CD195 / CCR5 (also known as CKR-5) is a receptor for inflammatory CC-chemokines (characterized by a pair of adjacent cysteine residues), such as MIP-1 alpha, MIP-1 beta, or RANTES. It is a G protein-associated seven-pass transmembrane protein expressed on resting T cells with memory/effector phenotype, monocytes, macrophages and immature dendritic cells. This chemokine receptor regulates the activation and directed migration of leukocytes. Importantly, along with CD4, CD195 / CCR5 functions as a major receptor for HIV. Their ligand is the viral glycoprotein gp120. |
| Alias Names | CKR5, CCR5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5 |
| Previous Article No | AFC-4822-2 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. |
| Purification | Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Research area | Cell Signaling |
| Size | 100 tests |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
| Substrate / Buffer | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody T21/8 recognizes an extracellular epitope on the N-teminus of CD195, an approximately 45 kDa G-protein coupled receptor 1 family protein expressed on resting T cells, monocytes, macrophages, and immature dendritic cells. |
| UniProt Number | P51681 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
