Article No
AFC-XXF64V-0.1
Anti-Ms CD18 Purified Low Endotoxin
Anti-Ms CD18 Purified Low Endotoxin
Antibodies Primary
Specifications
| Application | FC, IP, WB, IHC |
| Article No | AFC-XXF64V-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | M18/2 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-Ms CD18 Purified Low Endotoxin |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 16414 |
| Format | Purified Low Endotoxin |
| Immunogen | Murine cytotoxic T cell glycoproteins |
| Isotype | IgG2a |
| Keywords | CD and Related Antigens & MHC (Rodent) |
| Notes | CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. |
| Alias Names | Integrin beta2, Complement receptor C3 subunit beta, ITGB2 |
| Previous Article No | AFC-4652-2, AFC-XXF64V-0.1 |
| Product Type | Antibodies Primary |
| Protocol | Functional application: Blocking or stimulation. Flow cytometry: Recommended dilution: 1 μg/ml. |
| Purification | Purified by protein-G affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Research area | Immunology |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | mouse |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4 |
| Technical Specifications | The rat monoclonal antibody M18/2 recognizes an extracellular epitope of CD18 antigen (integrin beta2 subunit; beta2 integrin), a 95 kDa type I transmembrane protein expressed on all leukocytes. |
| UniProt Number | P11835 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
