Article No
A57199-100
Capsid Protein VP2 Polyclonal Antibody, FITC Conjugated
Capsid Protein VP2 Polyclonal Antibody, FITC Conjugated
Antibodies Primary
Specifications
| Application | ELISA |
| Article No | A57199-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
| Clone Type | polyclonal |
| Conjugation | FITC |
| Description | Capsid Protein VP2 Polyclonal Antibody, FITC Conjugated |
| Supplier | Epigentek |
| Immunogen | Recombinant Human parvovirus B19 Capsid protein VP2 protein (228-781AA) |
| Isotype | IgG |
| Keywords | Immunology & Inflammation |
| Notes | Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors, such as the glycosphingolipid globoside or the integrin heterodimer ITGAV/ITGB1. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell. Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids. |
| Alias Names | Coat protein VP1, Coat protein VP2 |
| Product Type | Antibodies Primary |
| Purity | Protein G purified |
| Research area | Immunology |
| Size | 100 µl |
| Source / Host | rabbit |
| Species Reactivity | virus |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. |
| Substrate / Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
| UniProt Number | P07299 |
| Product Page Updated | 2024-02-13T10:42:34.821Z |
