Article No
A52169-100
AGER Polyclonal Antibody, Biotin Conjugated
AGER Polyclonal Antibody, Biotin Conjugated
Antibodies Primary
Specifications
| Application | ELISA |
| Article No | A52169-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, GL |
| Clone Type | polyclonal |
| Conjugation | Biotin |
| Description | AGER Polyclonal Antibody, Biotin Conjugated |
| Supplier | Epigentek |
| Immunogen | Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA) |
| Isotype | IgG |
| Keywords | Immunology & Inflammation, Signal Transduction |
| Notes | Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. _x000D_ |
| Alias Names | Receptor for advanced glycosylation end products, AGER, RAGE |
| Product Type | Antibodies Primary |
| Purity | Protein G purified |
| Research area | Immunology |
| Size | 100 µl |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. |
| Substrate / Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
| UniProt Number | Q15109 |
| Product Page Updated | 2024-02-13T10:42:34.821Z |
