Article No
36-3379-100
XRCC3
Anti-XRCC3 Monoclonal Antibody(Clone: 10F1/6)
Antibodies Primary
Specifications
| Application | IHC, WB |
| Article No | 36-3379-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 10F1/6 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Anti-XRCC3 Monoclonal Antibody(Clone: 10F1/6) |
| Supplier | Abeomics |
| Entrez Gene ID | 7517 |
| Gene Symbol | XRCC3 |
| Immunogen | Recombinant full-length human XRCC3 protein |
| Isotype | IgG1 k |
| Notes | The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA Ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA Ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA Ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation. |
| Alias Names | CMM6; DNA repair protein XRCC3; RAD51 like; X ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross-complementing protein 3; XRCC3 |
| Product Type | Antibodies Primary |
| Protocol | Western Blot (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C, -80°C |
| Substrate / Buffer | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| UniProt Number | O43542 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
