Article No
333-A7022-25g
Specifications
| CAS No | 148893-10-1 |
| MW | 380.2 |
| Article No | 333-A7022-25g |
| Country Availability | SE, FI, DK, NO, IS, EE, FO, GL |
| Description | used in peptide coupling chemistry |
| Supplier | APExBIO |
| Notes | HATU(1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used inpeptide couplingchemistry to generate an active ester from a carboxylic acid. HATU can be used along with Huenig's base(N,N-diisopropylethylamine, DIPEA) to form amide bonds. The general solvent is DMF [1]. HATU has been commonly used in alcohol and amine acylation reactions such as amide and ester formation. Such reactions are commonly performed in two distinct reaction steps: (1) reaction of a carboxylic acid with HATU to form the OAt-active ester; then (2) addition of the nucleophile to the active ester solution to form the acylated product such as alcohol or amine [2, 3].References:[1]. Carpino L A. 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive[J]. Journal of the American Chemical Society, 1993, 115(10): 4397-4398.[2]. Carpino L A, Imazumi H, El-Faham A, et al. The uronium/guanidinium peptide coupling reagents: Finally the true uroniumsalts[J]. AngewandteChemie International Edition, 2002, 41(3): 441-445.[3]. Carpino L A, Imazumi H, Foxman B M, et al. Comparison of the Effects of 5-and 6-HOAt on Model Peptide Coupling Reactions Relative to the Cases for the 4-and 7-Isomers[J]. Organic letters, 2000, 2(15): 2253-2256. |
| Molecular Formula | C10H15F6N6OP |
| Previous Article No | 333-A7022-25G |
| Product Type | Sample Preparation |
| Purity | 98% |
| Shipping Information | BLUE ICE |
| Size | 25 g |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥16 mg/mL in DMSO |
| Storage | -20°C |
| Product Page Updated | 2024-03-05T10:50:49.934Z |
