Article No
303-X2769B
Histone H2a.x (S140)
Histone H2a.x (S140)
Proteins & Peptides
Specifications
| Application | Block |
| Article No | 303-X2769B |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Concentration | See vial for concentration |
| Description | Histone H2a.x (S140) |
| Supplier | Exalpha Biologicals |
| Notes | This peptide is the immunogen used to make Cat # X2754P. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Blocking Peptide to Cat # X2754P. |
| Alias Names | H2AFX; H2AX |
| Product Type | Proteins & Peptides |
| Protocol | Optimal concentration should be evaluated by serial dilutions. |
| Shipping Information | Ship at ambient temperature, freeze upon arrival |
| Size | 50 µg |
| Stability | See expiration date on vial |
| Storage | Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles |
| Substrate / Buffer | Provided as solution in phosphate buffered saline with 0.08% sodium azide |
| Technical Specifications | Optimal concentration should be evaluated by serial dilutions. |
| Product Page Updated | 2023-12-29T14:25:47.027Z |
