Article No
303-X1626M
Mouse anti Human Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6), conjugated with FITC
Mouse anti Human Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6), conjugated with FITC
Antibodies Primary
Specifications
| Application | WB, FC |
| Article No | 303-X1626M |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Clone | 1 |
| Clone Type | monoclonal |
| Concentration | See vial for concentration |
| Conjugation | FITC |
| Control Tissue | Not Available |
| Description | Mouse anti Human Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6), conjugated with FITC |
| Supplier | Exalpha Biologicals |
| Immunogen | Hybridoma produced by the fusion of splenocytes from mice immunized with Unique synthetic peptide derived from the C-terminal of the EDG6 (S1P4) protein and mouse myeloma cells. |
| Isotype | IgG1 |
| Notes | EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG6 (S1P4) receptor is the sphingosine 1-phosphate receptor-4 (S1P4). |
| Alias Names | Endothelial cell differentiation gene 6 C-terminal; Sphingosine-1-Phosphate Receptor-4 (S1P4) |
| Product Type | Antibodies Primary |
| Protocol | The X1626M antibody can be used for flow cytometry (use 1 µg of antibody per 106 cells). NOTE: Epitope for the antibody is the C-terminal region of the EDG6 protein. The C-terminus is an intracellular region and cells need to be permeablized prior to staining with antibody. Optimal concentration should be evaluated by serial dilutions. |
| Purification | Protein A/G Chromatography |
| Research area | Cell Signaling |
| Shipping Information | Ship at ambient temperature |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Stability | See expiration date on vial |
| Storage | Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles |
| Substrate / Buffer | Provided as solution in phosphate buffered saline with 0.08% sodium azide |
| Technical Specifications | Antibody can be used for flow cytometry (use 1 µg of antibody per 106 cells). NOTE: Epitope for the antibody is the C-terminal of the EDG6 protein. The C-terminal is an intracellular region and cells need to be permeablized prior to staining with antibody. Optimal concentration should be evaluated by serial dilutions. |
| UniProt Number | O95977 |
| Product Page Updated | 2023-12-29T14:25:47.027Z |
