Article No
30-2073-0.1
CD8b
Anti-CD8b Monoclonal Antibody (Clone:341)-FITC Conjugated
Antibodies Primary
Specifications
| Application | FA, FC, IHC, IP, WB |
| Article No | 30-2073-0.1 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 341 |
| Clone Type | monoclonal |
| Conjugation | FITC |
| Description | Anti-CD8b Monoclonal Antibody (Clone:341)-FITC Conjugated |
| Supplier | Abeomics |
| Entrez Gene ID | 24931 |
| Gene Symbol | Cd8b |
| Immunogen | CD8 positive Wistar rat splenic T cell hybridomas |
| Isotype | IgG1 |
| Notes | The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling. |
| Alias Names | Cd8b||Cd8b1, CD8 antigen 37 kDa chain, OX-8 membrane antigen |
| Product Type | Antibodies Primary |
| Shipping Information | Blue Ice |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | rat |
| Storage | 4°C |
| UniProt Number | P05541 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
