Article No
30-1945-100
CD18 / Integrin beta2 subunit
Anti-CD18 / Integrin beta2 subunit Monoclonal Antibody (Clone:MEM-48)-FITC Conjugated
Antibodies Primary
Specifications
| Application | FA, FC, IHC, IP, WB |
| Article No | 30-1945-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | MEM-48 |
| Clone Type | monoclonal |
| Conjugation | FITC |
| Description | Anti-CD18 / Integrin beta2 subunit Monoclonal Antibody (Clone:MEM-48)-FITC Conjugated |
| Supplier | Abeomics |
| Entrez Gene ID | 3689 |
| Gene Symbol | ITGB2 |
| Immunogen | Leukocytes of a patient suffering from a LGL-type leukemia. |
| Isotype | IgG1 |
| Notes | CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. |
| Alias Names | ITGB2||CD18||MFI7 |
| Product Type | Antibodies Primary |
| Shipping Information | Blue Ice |
| Size | 100 Tests |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| UniProt Number | P05107 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
