Article No
30-1798-100
CD79b
Anti-CD79b Monoclonal Antibody (Clone:CB3-1)-APC Conjugated
Antibodies Primary
Specifications
| Application | FC, IP, WB |
| Article No | 30-1798-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | CB3-1 |
| Clone Type | monoclonal |
| Conjugation | APC |
| Description | Anti-CD79b Monoclonal Antibody (Clone:CB3-1)-APC Conjugated |
| Supplier | Abeomics |
| Entrez Gene ID | 974 |
| Gene Symbol | CD79B |
| Immunogen | Fraction of Ig-associated molecules isolated from Ramos B cells |
| Isotype | IgG1 |
| Notes | CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
| Alias Names | CD79B||B29||IGB |
| Product Type | Antibodies Primary |
| Shipping Information | Blue Ice |
| Size | 100 Tests |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| UniProt Number | P40259 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
