Article No
182-HM2320-20UG
Complement factor I, Human, mAb 1C11 – 20 µg
Complement factor I, Human, mAb 1C11 – 20 µg
Antibodies Primary
Specifications
| Application | IA, WB |
| Article No | 182-HM2320-20UG |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Clone | 1C11 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Complement factor I, Human, mAb 1C11 – 20 µg |
| Supplier | Hycult biotechnology |
| Format | 0.2 ml (100 μg/ml) 0.2 μm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide. |
| Immunogen | Complement factor I |
| Isotype | IgG1 |
| Notes | The monoclonal antibody 1C11 recognizes Complement Factor I (CFI). CFI is a protein of the complement system (serine protease) , also known as as C3b/C4f inactivator, and is a protein that is encoded by the CFI gene located on chromosome 4. It regulates complement activation by cleaving cellbound or fluid phase C3b and C4b. CFI is synthesised predominantly in the liver, and is initially secreted as a single 88 kDa gene product; this precursor protein is then cleaved by furin to yield the mature CFI protein, which is a disulfide-linked dimer of heavy chain residues (residue 19-335, 51 kDa) and light chain (residues 340-583, 37 kDa). Only the mature protein is active. Genetic polymorphism in CFI has been observed (variants R201S, R406H, R502L). CFI deficiency leads to low levels of complement component 3 (C3) in plasma, due to unregulated activation of the complement alternative pathway, and it has been associated with recurrent bacterial infections in children; more recently, mutations in the CFI gene have been shown to be implicated in development of Haemolytic Uremic Syndrome, a renal disease also caused by unregulated complement activation. The monoclonal antibody can be used to detect CFI levels in serum and plasma. |
| Previous Article No | 182-HM2320-20UG, HM2320-20UG |
| Product Type | Antibodies Primary |
| Research area | Immunology |
| Shipping Information | Room Temperature |
| Size | 20 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label. |
| Substrate / Buffer | 0.2 ml (100 μg/ml) 0.2 μm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide. |
| Product Page Updated | 2024-04-05T09:42:44.568Z |
