Article No
182-HM2238-100UG
Beta2-adrenoceptor, Human, mAb 6H8 – 100 µg
Beta2-adrenoceptor, Human, mAb 6H8 – 100 µg
Antibodies Primary
Specifications
| Application | FC, FS, IA |
| Article No | 182-HM2238-100UG |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Clone | 6H8 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Beta2-adrenoceptor, Human, mAb 6H8 – 100 µg |
| Supplier | Hycult biotechnology |
| Format | 1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin |
| Immunogen | Free peptide Beta2-H19C |
| Isotype | IgG1 |
| Notes | The monoclonal antibody 6H8 recognizes human beta2-adrenoceptor. The b -adrenoceptors can be divided into b1, b2, b3 and b4-adrenoceptors defined in terms of agonist potencies, b2-adrenoceptors displayed a higher selectivity for nor-adrenaline than for adrenaline. B2-receptors are mainly postsynaptic and are located on a number of tissues including blood vessels, bronchi, GIT, skeletal muscle, liver and mast cell. Activation results in vasodilatation, bronchodilation, relaxation of the GIT, glycogenolysis in the liver, tremor in skeletal muscle and inhibition of histamine release from mast cells.- Transduction is via G-proteins coupled to the intracellular second messenger adenylate cyclase. B-receptors are positively coupled to adenylate cyclase via activation of Gs G-protein, however activation of the b2-adrenoceptors results in stimulation and inhibition of adenylate cyclase. The b2-receptor selective agonists are widely used in the treatment of asthma and other related bronchospastic conditions. They are commonly used in the treatment of angina pectoris, cardiac arrhythmia and for the long-term treatment of patients who survive myocardial infarction. B-receptor antagonists have also been used as anti-hypertensive for a number of years. Beta -blockers have also proven useful in the treatment of conditions such as migraine, anxiety disorders, hyperthyroidism, alcohol withdrawal and when applied topically are useful in the treatment of glaucoma and ocular hypertension. |
| Previous Article No | 182-HM2238, 182-HM2238-100UG, HM2238-100UG |
| Product Type | Antibodies Primary |
| Research area | Neuroscience |
| Shipping Information | Room Temperature |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label. |
| Substrate / Buffer | 0.2 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin |
| Product Page Updated | 2024-04-05T09:42:44.568Z |
