Article No
182-HM2055-20UG
IL-1ra3, Human, mAb 2D11 – 20 µg
IL-1ra3, Human, mAb 2D11 – 20 µg
Antibodies Primary
Specifications
| Application | IA, WB |
| Article No | 182-HM2055-20UG |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Clone | 2D11 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | IL-1ra3, Human, mAb 2D11 – 20 µg |
| Supplier | Hycult biotechnology |
| Format | 0.2 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin. |
| Isotype | IgG1 |
| Notes | The antibody reacts specificly with Human IL-1ra3. IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1 ra type II (IL-1ra3), have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is to limit the pro-inflammatory action of cell debris. Studies have shown that IL-1ra3 is expressed by various cell types upon exposure to inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes. |
| Previous Article No | 182-HM2055-20UG, HM2055-20UG |
| Product Type | Antibodies Primary |
| Research area | Immunology |
| Shipping Information | Room Temperature |
| Size | 20 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year. |
| Substrate / Buffer | 0.2 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin. |
| Product Page Updated | 2024-04-05T09:42:44.568Z |
