Article No
155-99-410
NCBI Number | 7412 |
Accession Number | P19320 |
Application | FC |
Article No | 155-99-410 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 1.G11B1 |
Clone Type | monoclonal |
Concentration | Lot specific |
Conjugation | Biotin |
Description | CD106 Antibody [1.G11B1] (Biotin) |
Supplier | ProSci |
Entrez Gene ID | 7412 |
Format | Liquid |
Gene Symbol | VCAM1 |
Isotype | IgG1 |
Notes | CD106, also known as INCAM-110, is a 110 kDa vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine-activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages, and bone marrow stromal cells. Endothelial CD106 binds the integrins alpha4beta1 (CD49d/CD29, VLA-4) and alpha4beta7 and contributes to extravasation of lymphocytes, monocytes, basophils, and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the beta2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development. The monoclonal antibody 1.G11B1 inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium. |
Alias Names | VCAM-1, INCAM-110, vascular cell adhesion molecule-1 |
Previous Article No | 155-99-410-100 |
Product Type | Antibodies Primary |
Protocol | CD106 Antibody [1.G11B1] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, and ELISA assays. |
Research area | Neuroscience |
Shipping Information | BLUE ICE |
Size | 100 tests |
Source / Host | mouse |
Species Reactivity | human, pig/porcine |
Storage | 4°C |
Substrate / Buffer | Supplied in PBS/NaN3 |
Technical Specifications | CD106 Antibody [1.G11B1] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, and ELISA assays. |
UniProt Number | P19320 |
Product Page Updated | 2024-01-03T13:34:25.701Z |