Article No
155-96-778
VLDLR Recombinant Protein
VLDLR Recombinant Protein
Proteins & Peptides
Specifications
| MW | 83 kDa, The protein migrates as 110-120 kDa under reducing (R) condition (SDS-Page) due to different glycosylation. |
| NCBI Number | 7436 |
| Accession Number | AAI42654 |
| Application | WB |
| Article No | 155-96-778 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Description | VLDLR Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 7436 |
| Format | Lyophilized |
| Gene Symbol | VLDLR |
| Notes | The very-low-density-lipoprotein receptor (VLDL-R) is a lipoprotein receptor that shows considerable similarity to the lowdensity-lipoprotein receptor. VLDL R is a 130 kDa type I transmembrane protein in the LDL receptor family that plays a significant role in lipid metabolism and in nervous system development and function .This receptor has been suggested to be important for the metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, such as very-low-densitylipoprotein (VLDL), beta-migrating VLDL and intermediate-density lipoprotein. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. In humans, the VLDL-R is encoded by the VLDLR gene. A rare neurological disorder first described in the 1970s under the name "disequilibrium syndrome" is now considered to be caused by the disruption of VLDLR gene. The disorder was renamed VLDLR-associated cerebellar hypoplasia (VLDLRCH) after a 2005 study. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. VLDLRCH is one of the two known genetic disorders caused by a disruption of reelin signaling pathway, along with Norman-Roberts syndrome. |
| Alias Names | VLDLR, RP11-320E16.1, CHRMQ1, FLJ35024, VLDLRCH, VLDL receptor |
| Previous Article No | 155-96-778-0.1 |
| Product Type | Proteins & Peptides |
| Protocol | This recombinant protein can be used for WB. For research use only. |
| Purity | >97% |
| Sequence | Gly 28 - Ser 797 |
| Shipping Information | RT |
| Size | 0.1 mg |
| Storage | -20°C, -80°C |
| Substrate / Buffer | PBS, pH7.4 |
| Technical Specifications | Measured by its binding ability in a functional ELISA. When Recombinant Human Apolipoprotein E3 is immobilized at 1μg/ml (100μl/well), the concentration of Recombinant Human VLDLR that produces 50% of the optimal binding response is found to be approximately 0. 03 - 0. 15μg/ml. |
| UniProt Number | P98155 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
