Article No
155-90-390
CD27 Recombinant Protein
CD27 Recombinant Protein
Proteins & Peptides
Specifications
| NCBI Number | 939 |
| Accession Number | AAH12160 |
| Article No | 155-90-390 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Description | CD27 Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 50723,939 |
| Format | Lyophilized |
| Gene Symbol | CD27, Icosl |
| Notes | CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis. |
| Alias Names | T Cell Activation Antigen CD27, T14, TNFRSF7, Tumor Necrosis Factor Receptor Superfamily Member 7, S152 |
| Previous Article No | 155-90-390-100 |
| Product Type | Proteins & Peptides |
| Protocol | This recombinant proteins is for research use only. |
| Purity | ≥98% |
| Research area | Cell Death |
| Sequence | The extracellular domain of human CD27 (aa 21-192) is fused to the N-terminus of the Fc region of human IgG1. |
| Shipping Information | RT |
| Size | 100 ug |
| Storage | -20°C |
| Substrate / Buffer | Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μl sterile water. Add 1X PBS to the desired protein concentration. |
| Technical Specifications | Measured by its ability to inhibit the proliferation of mouse T cells induced by CD27 ligand and anti-CD3. |
| UniProt Number | Q9JHJ8 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
