Article No
155-40-166-0.002
VEGF-D Recombinant Protein
VEGF-D Recombinant Protein
Proteins & Peptides
Specifications
| NCBI Number | 2277 |
| Accession Number | NP_004460.1 |
| Article No | 155-40-166-0.002 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Description | VEGF-D Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 2277 |
| Format | Lyophilized |
| Gene Symbol | VEGFD |
| Notes | VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 13.1 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition. |
| Alias Names | VEGFD, VEGF-D, VEGFD, Vascular endothelial growth factor D, c-Fos-induced growth factor |
| Product Type | Proteins & Peptides |
| Purity | >95% |
| Sequence | FAATFYDIET LKVIDEEWQR TQCSPRETCV EVASELGKST NTFFKPPCVN VFRCGGCCNE ESLICMNTST SYISKQLFEI SVPLTSVPEL VPVKVANHTG CKCLPTAPRH PYSIIRR |
| Shipping Information | RT |
| Size | 0.002mg |
| Storage | The lyophilized VEGF-D recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted VEGF-D is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing VEGF-D recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
| UniProt Number | O43915 |
| Product Page Updated | 2024-01-03T13:15:21.507Z |
