Article No
155-36-179
Specifications
| NCBI Number | 835 |
| Accession Number | 83300977 |
| Application | ELISA, FC, ICC, IHC, IP, WB |
| Article No | 155-36-179 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 11B4 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Caspase-2 Antibody [11B4] |
| Supplier | ProSci |
| Entrez Gene ID | 835 |
| Format | Liquid |
| Gene Symbol | CASP2 |
| Immunogen | Recombinant human caspase-2 (p19 subunit). |
| Isotype | IgG2a k |
| Notes | Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase. |
| Alias Names | CASP-2; Protease ICH-1; Neural Precursor Cell Expressed Developmentally Down-regulated Protein 2; NEDD-2 |
| Previous Article No | 155-36-179-100 |
| Product Type | Antibodies Primary |
| Protocol | Immunoprecipitation: (1-5ug/ml) . Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application. |
| Purification | >95% (SDS-PAGE) |
| Research area | Cell Death |
| Shipping Information | BLUE ICE |
| Size | 100 ug |
| Source / Host | rat |
| Species Reactivity | dog/canine, human, monkey, mouse, rat |
| Storage | -20°C |
| Substrate / Buffer | Liquid. In PBS containing 0.02% sodium azide. |
| UniProt Number | P42575 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
