Article No
12-1198-100
Insulin / IRDN (beta-Cell & Insulinoma Marker)
Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rIRDN/805)
Antibodies Primary
Specifications
| Application | IHC |
| Article No | 12-1198-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | rIRDN/805 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rIRDN/805) |
| Supplier | Abeomics |
| Entrez Gene ID | 3630 |
| Gene Symbol | INS |
| Immunogen | Recombinant full-length human IRDN protein |
| Isotype | IgG1 k |
| Notes | Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected throµgh the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker. |
| Alias Names | IDDM2, ILPR, IRDN, MODY10, Proinsulin |
| Product Type | Antibodies Primary |
| Protocol | Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) |
| Purification | Protein A/G Purified |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human, mouse |
| Storage | 4°C, -80°C |
| Substrate / Buffer | 200 µg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| UniProt Number | P01308 |
| Product Page Updated | 2024-02-06T07:35:53.072Z |
