Article No
10-4059-100
Application | WB |
Article No | 10-4059-100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | ABM2D87 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Monoclonal Antibody to TSLP Receptor (Clone: ABM2D87) |
Supplier | Abeomics |
Entrez Gene ID | 64109 |
Gene Symbol | CRLF2 |
Immunogen | A partial length recombinant TSLPR protein (amino acids 97-252) was used as the immunogen for this antibody. |
Isotype | IgG2b k |
Keywords | Immunology, CRLF2, 64109, Q9HC73, CRLF2, CRL2, ILXR, TSLPR, ABM2D87, Monoclonal Antibody to TSLP Receptor(Clone :ABM2D87), Anti TSLP Receptor Antibody, TSLP Receptor Antibody |
Notes | TSLPR (thymic stromal lymphopoietin receptor) also known as CRLF2 (cytokine receptor-like factor 2) is a member of type I cytokine receptor. It binds its ligand TSLP (thymic stromal lymphopoietin) as a heterodimer with IL7R. TSLP ligand is produced by epithelial cells in order to activate dendritic cells, and is involved in inflammation, allergic responses as well as B-cell precursor proliferation and survival. The interaction between TSLP and its heterodimeric receptor activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. High expression of CRLF2 is associated with a poor prognosis in adult and high-risk pediatric cases of B-ALL (B-cell acute lymphoblastic leukemias). |
Alias Names | CRLF2||CRL2||ILXR||TSLPR |
Product Type | Antibodies Primary |
Protocol | Western blot analysis: 2-4 µg/ml |
Purification | Protein G Purified |
Research area | Immunology |
Shipping Information | Blue Ice |
Size | 100 µg |
Source / Host | mouse |
Species Reactivity | human |
Storage | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Substrate / Buffer | 100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
UniProt Number | Q9HC73 |
Product Page Updated | 2024-04-03T14:02:41.041Z |