Article No
10-3012-100
MyD88
Monoclonal antibody to MyD88 (Clone: ABM2H20)
Antibodies Primary
Specifications
| Application | FC, WB |
| Article No | 10-3012-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM2H20 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Monoclonal antibody to MyD88 (Clone: ABM2H20) |
| Supplier | Abeomics |
| Entrez Gene ID | 4615 |
| Gene Symbol | MYD88 |
| Immunogen | A partial length recombinant protein of human MyD88 (amino acids 13-221) was used as an immunogen for this antibody. |
| Isotype | IgG1 k |
| Keywords | TLR and Innate Immunity, MYD88, 4615, Q99836, , ABM2H20, Monoclonal Antibody to MyD88(Clone :ABM2H20), Anti MyD88 Antibody, MyD88 Antibody |
| Notes | MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway. |
| Alias Names | Myeloid differentiation primary response protein MyD88 |
| Product Type | Antibodies Primary |
| Protocol | Western blot analysis: 0.1-2 µg/ml; FACS Analysis: 0.5-1 µg/ml |
| Purification | Protein G Purified |
| Research area | Immunology |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human, mouse |
| Storage | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
| Substrate / Buffer | 100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | Q99836 |
| Product Page Updated | 2024-05-08T07:23:11.080Z |
