Promotion

Now 50% off on over 1500 Kinases!

Kinases are one of the largest classes of enzymes, with 516 family members, they constitute ~2% of all human genes. Kinases catalyze the transfer of the γ-phosphate from ATP to acceptor hydroxyl groups on amino acids (such as serine, threonine and tyrosine) in proteins or glycosyl moieties in lipids. This process, termed phosphorylation, is the most efficient way to regulate protein and lipid function in cells and is considered a key step in posttranslational modification of proteins and lipids kinases. Phosphorylation usually results in a functional change of the substrate or target protein such as a change in its enzyme activity, cellular localization, or association with other proteins. Protein and lipid kinases are not only present in humans, but also are readily found in bacteria and plants.

Protein kinase activity is highly regulated, allowing it to participate in diverse signaling pathways in within the cell. Growth factors, cytokines and hormones can turn on or off the activity of various protein kinases, thereby regulating the function of downstream substrate proteins. Due to the key regulatory function of protein kinases on cellular pathways, they are often highly associated with diseases. Defective signaling by protein kinases accounts for more than 400 human diseases. Today, these targets are still being actively pursued for therapeutic intervention. Research geared toward targeting protein kinases by small molecule inhibitors or neutralizing antibodies has been extremely beneficial in the treatment of various human diseases such as cancer. Over 160 protein kinases have been shown to be associated with human diseases, and numerous kinases have been found as the drug targets which are being developed and under approval by the FDA.

SignalChem offers a diverse and comprehensive range of serine/threonine kinases, receptor tyrosine kinases, cytoplasmic tyrosine kinases and lipid kinases for drug discovery efforts and functional studies.

Nordic BioSite and SignalChem now offer these at a very favorable price! View all discounted Kinases HERE.

 


Terms & Conditions

  1. Listed price indicateds already discounted price (territory deviations may apply)
  2. Valid until December 31st 2020
  3. SignalChem & Nordic BioSite reserves the right to change or withdraw the offer at any time
  4. This offer cannot be combined with any other ongoing promotional offer and/or quote