GeneTex – Antibody Trials

Nordic BioSite is a proud distributor of the whole range of Genetex product range. Genetex has been in the business for 20 years, starting off in the fields of breast cancer biology and prognostic marker research. GeneTex’s product portfolio now cover research areas including cancer, cell biology, epigenetics, immunology, infectious disease, metabolism, neuroscience, signal transduction, stem cell development and zebrafish biology.

 

GeneTex is committed to the highest standards of product performance through their stringent quality control process.

 

To meet this mission, they resolve to abide by the validation guidelines proposed by the International Working Group on Antibody Validation (IWGAV) 1 including genetic strategies (see their knockout/knockdown program) and independent antibody strategies (see their side-by-side program).

 

GeneTex has been conducting side-by-side western blot (WB) and immunohistochemistry (IHC) studies comparing GeneTex reagents to their competitors targeting the same proteins. There goal is to provide highly validated and high-quality GeneTex antibodies to assist you to attain the best possible results with their products.

Cancer

There are over 100 different types of cancer, with often significant genotypic and phenotypic heterogeneity even among tumors of the same kind. Research is one of the best weapons to oppose this scourge, and great progress has been made in cancer diagnosis, treatment, and prevention. In addition, scientists have made enormous strides dissecting the mechanisms and pathways that drive carcinogenesis and metastasis, and in offering approaches as to how these processes can be potentially targeted for therapeutic purposes.

Featured Products

 

 

PARP antibody [GT6212] (GTX628836) 
 

Poly (ADP-ribose) polymerases (PARPs) are enzymes catalyzing the transfer of ADP-ribose to target proteins. PARPs play an important role in various cellular processes such as DNA repair, chromatin structure modulation, and different types of cell death. Caspase-3 cleavage of PARP is considered a hallmark of apoptosis. On the other hand, the elevated PARP-1 activity may trigger high NAD+ consumption (depleting ATP pools) and thus induces necrosis.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Her2 / ErbB2 antibody [C2C3], C-term (GTX100509) 

HER2 is one of the HER/EGFR/ERBB family members with tyrosine kinase activity. HER2 overexpression has been linked to the development and progression of certain aggressive types of cancer, particularly in breast and gastric/gastroesophageal cancer. Overexpression of HER2 increases receptor dimerization, autophosphorylation and initiates a variety of signaling pathways leading to cell proliferation and tumorigenesis. Her2 is an important biomarker and therapeutic target for approximately 30% of breast cancer patients.

 

 

 

 

 

 

 


  

 

 

 

 

 

CD44 antibody [GT462] (GTX628895)

Cancer stem cells (CSCs) are being increasingly being recognized as the key determinative cells of malignancies. CD44 is a glycosylated cell surface receptor for hyaluronic acid (HA) and many other ECM components. CD44 exists as a standard isoform (CD44s) and a range of variant isoforms (CD44v) generated through alternative splicing. Accumulating evidence suggests that CD44 is a CSC marker and critical regulators of CSC self-renewal, tumor initiation, metastasis, and chemoradioresistance properties.

 

 

 

 

 

  

 

Bmi1 antibody (GTX102020) 

Bmi1 is a core component of the polycomb repressive complex 1 (PRC1) regulating cell cycle genes. Bmi1 plays key roles in the self-renewal of hematopoietic stem cells (HSC), neural stem cells (NSC) and cancer stem cells (CSC). Clinically, increased Bmi1 expression levels have been shown to correlate with tumor metastasis, chemoresistance, and recurrence of CSCs in several aggressive cancer types. 


  

 

 

 

 

 

 

 

 

 

 

 

 

Bad antibody (GTX130108)

Bad is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. Bad positively regulates apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their anti-apoptotic activity. The pro-apoptotic function of Bad is negatively regulated through its phosphorylation. Phosphorylated Bad binds to 14-3-3 protein and dissociated from BCL-xL and BCL-2, thus promote cell survival.

 

 

 


  

 

 

 

 

 

E-Cadherin antibody [GT477] (GTX629691) 

E-cadherin is a calcium dependent cell-cell adhesion glycoprotein in the cadherin superfamily. E-cadherin is a well-known tumor suppressor protein, and the loss of its expression in tumor cells, in association with the epithelial-mesenchymal transition (EMT), occurs frequently during tumor progression and metastasis.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Special Offer No.1 - Ends 31st August 2018!

Join in the '10 ul sample program', where you can get 10 µl for 10 EUR or 100 SEK/DKK/NOK respectively until 31st August 2018!

As there are many researchers who are influenced by the discontinued supply of polyclonal antibodies, GeneTex and Nordic BioSite is happy to assist researchers to find suitable replacements of high quality and continue the research. We have selected 20 top cited antibodies and offer them for testing in this campaign. Then on a bimonthly basis, we will offer a new set of 20 antibodies, so stay tuned! 

 

View Featured Products!

 

Please also note that the offer is only valid for up to max 3 items per customer each month, and those customers providing feedback within one month's time will get a 10% discount code on the same item purchased. Use promo code: GTX20 to claim this offer.

Please note that terms and conditions apply!