GeneTex Antibody Trials

 

Nordic BioSite is a proud distributor of the whole range of Genetex product range. Genetex has been in the business for 20 years, starting off in the fields of breast cancer biology and prognostic marker research. GeneTex’s product portfolio now cover research areas including cancer, cell biology, epigenetics, immunology, infectious disease, metabolism, neuroscience, signal transduction, stem cell development and zebrafish biology.

 

GeneTex is committed to the highest standards of product performance through their stringent quality control process.

 

To meet this mission, they resolve to abide by the validation guidelines proposed by the International Working Group on Antibody Validation (IWGAV) 1 including genetic strategies (see their knockout/knockdown program) and independent antibody strategies (see their side-by-side program).

 

GeneTex has been conducting side-by-side western blot (WB) and immunohistochemistry (IHC) studies comparing GeneTex reagents to their competitors targeting the same proteins. There goal is to provide highly validated and high-quality GeneTex antibodies to assist you to attain the best possible results with their products.

Epithelial-Mesenchymal Transition (EMT)

Epithelial-mesenchymal transition (EMT) occurs when largely adherent and polarized epithelial cells acquire the phenotype of more mobile mesenchymal cells. EMT not only facilitates morphogenesis during embryonic development but also promotes invasion and metastasis in tumors. Pathological EMT is associated with E-cadherin repression, which contributes to tumor progression. Various oncogenic pathways (involving, for example, TGF-beta, Wnt/beta-catenin, integrins, and Notch) induce EMT via cytoskeletal rearrangement and activation of E-cadherin repressors, including SNAI1, SNAI2, SIP1, ZEB1, and TCF3.

 

Highlighted Products 

 
           

E-Cadherin antibody (GTX629691

 

E-cadherin, a calcium-dependent cell-cell adhesion molecule, is a key component of the adherens junctions that are integral in cell adhesion and in maintaining the epithelial cell phenotype. Tumor progression is often associated with the loss of E-cadherin function and the transition to a more motile and invasive phenotype.

 


N-Cadherin antibody (GTX127345)

 

Cells that undergo EMT commonly switch from expressing E-cadherin to N-cadherin. The upregulation of N-cadherin expression promotes cell motility and invasion, which is linked to tumor metastasis.

 

 

 

 

 

 

alpha Smooth Muscle Actin antibody (GTX100034)

 

Alpha-smooth muscle actin (alpha-SMA) is the actin isoform that is predominately expressed within vascular smooth muscle cells and plays an important role in fibrogenesis. Alpha-SMA is also considered to be a mesenchymal marker during EMT.

 

 

Vimentin antibody (GTX100619)

 

Vimentin is an intermediate filament protein that is characteristically upregulated in cells undergoing EMT. During EMT, cytoskeletal intermediate filaments undergo a significant compositional change from keratin (epithelial cells) to vimentin (mesenchymal cells).

 

 

 

 

 

 

ZEB1 antibody (GTX105278)

 

ZEB1 is a zinc finger- and homeodomain-containing transcription factor that binds to the E-box of target promoters. Its binding to the CDH1 promoter leads to the gene’s repression and promotion of tumor invasion and metastasis by inducing EMT.

 

 

 

 

 

SNAI1 antibody (GTX125918)

SNAI1 is a zinc finger transcriptional repressor controlling EMT during embryogenesis and tumor progression. It interacts with several corepressors to repress specific target genes, such as the CDH1 (E-cadherin) gene.

 

Full product list

Cat. No. Product Name Clonality Species Reactivity Application
GTX629691 E-Cadherin antibody Ms mAb Hu,Ms,Rat WB, ICC/IF, IHC-P, FACS, IP
GTX112975 Cytokeratin 8 antibody Rb pAb Hu,Ms WB, ICC/IF, IHC-P, IP
GTX105624 Cytokeratin 18  antibody  Rb pAb Hu WB, ICC/IF, IHC-P
GTX112666 Cytokeratin 19 antibody Rb pAb Hu,Ms,Rat WB, ICC/IF, IHC-P
GTX129931 Desmoglein 3 antibody Rb pAb Hu WB, IP
GTX100459 MUC1 antibody Rb pAb Hu WB, ICC/IF, IHC-P, IP
GTX108592 ZO-1 antibody Rb pAb Hu,Ms WB, IHC-P
GTX100034 alpha Smooth Muscle Actin antibody Rb pAb Hu,Ms,Rat,Zfsh WB, ICC/IF, IHC-P, IHC-Fr
GTX112794 Fibronectin antibody Rb pAb Hu,Ms WB, ICC/IF, IHC-P, IP, ELISA
GTX130705 Integrin alpha 5 antibody Rb pAb Hu,Ms,Rat WB
GTX128839 Integrin beta 1 / CD29 antibody Rb pAb Hu,Ms,Rat,Dog WB, ICC/IF, IHC-P, IP
GTX100458 MMP9 antibody Rb pAb Hu,Ms,Bov WB, ICC/IF, IHC-P
GTX127345  N-Cadherin antibody Rb pAb Hu,Ms,Rat WB, ICC/IF, IHC-P, IHC-Fr
GTX130023 TGF beta 1 antibody Rb pAb Hu,Ms WB
GTX100619 Vimentin antibody Rb pAb Hu,Ms,Rat WB, ICC/IF, IHC-P, IHC-Fr, IP
GTX633010 beta Catenin antibody Ms mAb Hu,Ms WB, ICC/IF, IHC-P
GTX125918  SNAI1 antibody Rb pAb Hu,Ms,Rat WB, ICC/IF, IHC-P, IHC
GTX129237 TCF3 antibody Rb pAb Hu WB, ICC/IF, IP
GTX127310 Twist1/2 antibody Rb pAb Hu,Ms,Rat WB, IHC-P
GTX105278 ZEB1 antibody Rb pAb Hu,Ms WB, ICC/IF, IP, ChIP assay
GTX631940 ARID5A antibody Ms mAb Hu,Ms WB, IHC-Fr
GTX134542 CD11b antibody Rb pAb Ms WB
GTX134588 CDC42 antibody Rb pAb Hu,Ms,Rat WB
GTX633917 Dicer antibody Ms mAb Hu WB, ICC/IF
GTX132495 GEF-H1 antibody Rb pAb Dm WB
GTX134513 GLB1 antibody Rb pAb Ms,Rat WB
GTX133372 GSK3 beta antibody Rb pAb Hu WB
GTX634834 IKK beta antibody Ms mAb Hu WB
GTX133781 IL17A antibody Rb pAb Hu,Ms,Rat WB, IHC-P
GTX130278 KDM5A / Jarid1A / RBBP2 antibody Rb pAb Hu WB
GTX134234 MEK1 antibody Rb pAb Hu,Rat WB
GTX634832 MMP2 antibody Ms mAb Hu WB
GTX134086 NMDAR2A antibody Rb pAb Ms WB
GTX133368 pan Synuclein antibody Rb pAb Ms,Rat WB, ICC/IF, IHC-P, IHC-Fr
GTX634811 Park7 / DJ-1 antibody Ms mAb Hu WB
GTX134478 PER2 antibody Rb pAb Hu,Ms WB
GTX129275 PERK antibody Rb pAb Hu WB
GTX134256 PKC eta antibody Rb pAb Ms WB
GTX634796 PKM antibody Ms mAb Hu,Ms,Rat WB
GTX634162 PYK2 antibody Ms mAb Hu WB
GTX633922 QKI antibody Ms mAb Hu,Ms,Rat WB, IHC-P
GTX134122 SLIT1 antibody Rb pAb Ms WB
GTX133724 SMARCA2 antibody Rb pAb Hu,Ms WB, ICC/IF, IHC-P
GTX633972 Synaptophysin antibody Ms mAb Ms,Rat WB, ICC/IF, IHC-P
GTX634809 Tau antibody Ms mAb Ms,Rat WB, ICC/IF
GTX134087 TMEM119 antibody Rb pAb Ms IHC-P, IHC-Fr
GTX131510 TMEM49 antibody Rb pAb Hu WB
GTX134541 Tropomyosin 4 antibody Rb pAb Hu WB
GTX134445 TRP2 antibody Rb pAb Hu WB
GTX129468 ZIC1 antibody Rb pAb Hu WB

 

Join in the '10 ul sample program', where you can get 10 µl for 10 EUR or 100 SEK/DKK/NOK respectively until April 30th 2019!

Use promo code: GTX20 to claim this offer.

 

As there are many researchers who are influenced by the discontinued supply of polyclonal antibodies, GeneTex and Nordic BioSite is happy to assist researchers to find suitable replacements of high quality and continue the research.

 

Please note that terms and conditions apply!  

Please also note that the offer is only valid for up to max 3 items per customer each month, and those customers providing feedback within one month's time will get a 10% discount code on the same item purchased (valid for 6 months). Use promo code: GTX20 to claim this offer.