GeneTex Antibody Trials

 

Nordic BioSite is a proud distributor of the whole range of Genetex product range. Genetex has been in the business for 20 years, starting off in the fields of breast cancer biology and prognostic marker research. GeneTex’s product portfolio now cover research areas including cancer, cell biology, epigenetics, immunology, infectious disease, metabolism, neuroscience, signal transduction, stem cell development and zebrafish biology.

 

GeneTex is committed to the highest standards of product performance through their stringent quality control process.

 

To meet this mission, they resolve to abide by the validation guidelines proposed by the International Working Group on Antibody Validation (IWGAV) 1 including genetic strategies (see their knockout/knockdown program) and independent antibody strategies (see their side-by-side program).

 

GeneTex has been conducting side-by-side western blot (WB) and immunohistochemistry (IHC) studies comparing GeneTex reagents to their competitors targeting the same proteins. There goal is to provide highly validated and high-quality GeneTex antibodies to assist you to attain the best possible results with their products.

RNA-binding Proteins

RNA-binding proteins (RBPs) bind to double- or single-stranded RNA through one or multiple RNA-binding motifs (RBMs) and change the fate or function of the bound RNAs. They play a major role in post-transcriptional control of RNAs, such as splicing, polyadenylation, mRNA stabilization, mRNA localization, and translation. The transcriptional and post-transcriptional regulation of RNAs by RBPs influences various biological processes such as embryogenesis, development and cellular metabolism. Aberrant expression of, and mutations in, particular RBP genes have been associated with various diseases ranging from neurological disorders to malignancies. 

 

Featured Products 

 
         

QKI antibody [GT1589] (GTX633920)

 

QKI belongs to the STAR (Signal Transducer and Activator of RNA) family of RNA-binding proteins. It regulates the differentiation of myelin-forming oligodendrocyte and Schwann cells. QKI is a candidate gene for several diseases including schizophrenia.

 


TDP43 antibody [GT225] (GTX630196)

 

TDP-43 is a member of the hnRNP family, and is the major component of intra-neuronal insoluble aggregates detected in degenerating neurons in patients affected by amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD). 

 

 

 

 

 

 

ESRP1 antibody (GTX131373)

ESRP1 (Epithelial Splicing Regulatory Protein 1) and ESRP2 regulate alternative splicing events in epithelial cells, and both are down-regulated during the epithelial-mesenchymal transition (EMT). These proteins also have important roles in tumor progression and metastasis.

 

 

SAM68 antibody [N2C3] (GTX115462)

 

SAM68 is a member of the STAR family of RNA-binding proteins. It is a multi-functional protein involved in signal transduction, cell cycle regulation, transcription, and alternative splicing. SAM68 is involved in the development and progression of spinal muscular atrophy and various cancers. 

 

 

 

 

 

 

TIA1 antibody [N1N3] (GTX113280) 

 

TIA1 is a member of the RNA-recognition motif (RRM) family of RNA-binding proteins. TIA1 plays roles in apoptosis, cellular stress, and inflammation. Importantly, TIA1 can translocate from the nucleus to stress granules, sites of translational repression in response to potentially damaging conditions, in response to a variety of environmental stresses. 

 

 

 

 

 

 

Join in the '10 ul sample program', where you can get 10 µl for 10 EUR or 100 SEK/DKK/NOK respectively until February 28th 2019!

 

As there are many researchers who are influenced by the discontinued supply of polyclonal antibodies, GeneTex and Nordic BioSite is happy to assist researchers to find suitable replacements of high quality and continue the research.

 

Please note that terms and conditions apply!  

Please also note that the offer is only valid for up to max 3 items per customer each month, and those customers providing feedback within one month's time will get a 10% discount code on the same item purchased (valid for 6 months). Use promo code: GTX20 to claim this offer.