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|Country Availability||DK, EE, FI, FO, GL, IS, LT, LV, NO, SE|
|Data Sheet Link||https://www.biossusa.com/store/datasheets/bs-1056R|
|Description||5-HTR2 Polyclonal Antibody|
|Entrez Gene ID||3356|
|Notes||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.|
|Alias Names||HTR2; 5-HT2A; 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; Serotonin receptor 2A; HTR2A|
|Protocol||WB(1:300-1000), IHC-P(1:200-400), IF(IHC-P)(1:50-200)|
|Purification||Purified by Protein A.|
|Source / Host||rabbit|
|Species Reactivity||human, mouse, rat|
|Storage||Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.|
|Technical Specifications||KLH conjugated synthetic peptide derived from human 5-HTR2A|
|Product Page Updated||2019-01-03T14:43:56.134Z|
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