Proteins & Peptides

14-3-3beta (human) (rec.)

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14-3-3beta (human) (rec.)

Article No

YIF-LF-P0040

Species Reactivity

human

Size

0.5 mg

Source / Host

bacteria

Product insert

Specifications

Article No YIF-LF-P0040
Description 14-3-3beta (human) (rec.)
Supplier Adipogen Life Sciences
Format Powder
Notes 14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms (beta, gamma, epsilon, eta, zeta, sigma and tau/theta) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.
Alias Names YWHAB
Product Type Proteins & Peptides
Purity >95% (SDS-PAGE)
References 1) Tzivion, G. et al. (2001) Oncogene, 20, 6331-6338. (General)2) Tzivion, G. and Avruch, J. (2002) J.Biol.Chem. 277, 3061-3064. (General)3) Berg, D. et al. (2003) Nat. Rev. Neurosci. 4(9), 752-762. (General)
Research Area Neuroscience
Size 0.5 mg
Source / Host bacteria
Species Reactivity human
Stability After reconstitution, store at -80°C.
Storage -20°C
Substrate / Buffer Lyophilized from 20mM Tris, 10mM NaCl, pH8.0.
Technical Specifications Protein. Lyophilized from 20mM Tris, 10mM NaCl, pH8.0. 14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms (beta, gamma, epsilon, eta, zeta, sigma and tau/theta) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.
Product Page Updated 2019-01-09T14:34:57.552Z

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