14-3-3beta (human) (rec.)

Article No YIF-LF-P0040
Product Type Proteins & Peptides
Research Area Neuroscience
Format Powder
Size 0.5 mg

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Specifications

Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/1078
Description 14-3-3beta (human) (rec.)
Supplier Adipogen Life Sciences
Notes Protein. Lyophilized from 20mM Tris, 10mM NaCl, pH8.0. 14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms (beta, gamma, epsilon, eta, zeta, sigma and tau/theta) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.
Alias Names YWHAB
Purity >95% (SDS-PAGE)
References 1) Tzivion, G. et al. (2001) Oncogene, 20, 6331-6338. (General)2) Tzivion, G. and Avruch, J. (2002) J.Biol.Chem. 277, 3061-3064. (General)3) Berg, D. et al. (2003) Nat. Rev. Neurosci. 4(9), 752-762. (General)
Source / Host bacteria
Species Reactivity human
Storage -20°C
Substrate / Buffer Lyophilized from 20mM Tris, 10mM NaCl, pH8.0.
Technical Specifications 14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms (beta, gamma, epsilon, eta, zeta, sigma and tau/theta) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.

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Source/Host:

bacteria

Species reactivity:

human human

Product insert:

Product data sheet

Datasheet