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Specifications
CAS No | 1357158-81-6 |
MW | 343.4 |
Article No | SYN-1160-M100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Description | AZD-26 |
Supplier | Adipogen Life Sciences |
Format | Powder |
Notes | AZD-26 is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC(50) of 422nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC(50) of 322nM. AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01µM to 10µM after 24 hour exposure in several rat and human cell models. Likewise AZD-25 used at 100-200mg/kg also inhibited AKT phosphorylation and subsequent activation.|Chemical. CAS: 1357158-81-6. Formula: C22H21N3O. MW: 343.4. AZD-26 is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC(50) of 422nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC(50) of 322nM. AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01µM to 10µM after 24 hour exposure in several rat and human cell models. Likewise AZD-25 used at 100-200mg/kg also inhibited AKT phosphorylation and subsequent activation. |
Molecular Formula | C22H21N3O |
Alias Names | AZD26 |
Product Type | Chemicals & Biochemicals |
Purity | >95% |
Research Area | Metabolism |
Shipping Information | RT |
Size | 100 mg |
Solubility | Soluble in DMSO or ethanol. |
Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Storage | -20°C, 4°C |
Technical Specifications | Chemical. CAS: 1357158-81-6. Formula: C22H21N3O. MW: 343.4. AZD-26 is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC(50) of 422nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC(50) of 322nM. AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01µM to 10µM after 24 hour exposure in several rat and human cell models. Likewise AZD-25 used at 100-200mg/kg also inhibited AKT phosphorylation and subsequent activation. |
Product Page Updated | 2024-02-01T08:25:01.492Z |