20S Proteasome (human) (untagged)

Article No SBB-PP0005-C050
Product Type Proteins & Peptides
Research Area Inflammation
Format Liquid
Size 50 µg

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Specifications

MW ~700kDa
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Concentration Lot dependent.
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/4970
Description 20S Proteasome (human) (untagged)
Supplier Adipogen Life Sciences
Notes Protein. Human 20S Proteasome. Source: Human Erythrocytes. Formulation: Liquid. In 50mM HEPES pH 7.6, 100mM sodium chloride, 1mM DTT. Purity: >95% (SDS-PAGE). The ubiquitin-proteasome pathway is the major proteolytic system in eukaryotic cells, where it catalyzes the selective degradation of short-lived regulatory proteins or the rapid turnover of misfolded proteins. One of the most important proteases in this pathway is the 26S proteasome, an ATP-dependent proteolytic complex, which is formed by the association of the barrel-shaped 20S proteasome (700kDa) and two 19S (700kDa) regulatory complexes. The 20S catalytic core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha-subunits and 2 rings are composed of 7 beta-subunits. The 20S catalytic core is able to degrade a variety of peptide substrates and poly-ubiquitinated proteins involved with apoptosis, DNA repair, endocytosis and cell cycle control.
Purity >95% (SDS-PAGE)
Sequence Human 20S Proteasome.
Species Reactivity human
Storage -80°C
Substrate / Buffer Liquid. In 50mM HEPES pH 7.6, 100mM sodium chloride, 1mM DTT.
Technical Specifications The ubiquitin-proteasome pathway is the major proteolytic system in eukaryotic cells, where it catalyzes the selective degradation of short-lived regulatory proteins or the rapid turnover of misfolded proteins. One of the most important proteases in this pathway is the 26S proteasome, an ATP-dependent proteolytic complex, which is formed by the association of the barrel-shaped 20S proteasome (700kDa) and two 19S (700kDa) regulatory complexes. The 20S catalytic core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha-subunits and 2 rings are composed of 7 beta-subunits. The 20S catalytic core is able to degrade a variety of peptide substrates and poly-ubiquitinated proteins involved with apoptosis, DNA repair, endocytosis and cell cycle control.

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Species reactivity:

human human

Product insert:

Product data sheet

Datasheet