2,2,7-trimethylguanosine

Article No RN019M
Product Type Antibodies Primary
Research Area Epigenetics
Application IP, ICC
Size 200 ug/200 uL

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Specifications

Country Availability SE, FI, DK, NO, IS, EE, LV, LT
Clone 235-1
Clone Type polyclonal
Conjugation Unconjugated
Data Sheet Link https://www.mblintl.com/assets/rn0019m-v1.pdf
Description Anti-2,2,7-trimethylguanosine (m3G/TMG) mAb
Supplier MBL International Corp.
CE/IVD false
Isotype IgG2a k
Notes Small nuclear RNA (snRNA) is known to be involved in pre-mRNA splicing as an RNA component of snRNP. 2,2,7-trimethylated guanosine (m3G/TMG) is a modified nucleoside at the 5&rsquo;-cap site of U snRNAs except for U6 snRNA. Shortly after transcription, 7-methylguanosine (m7G), called cap structure, is added to 5&rsquo;-end of <a>newly</a> synthesized U snRNA and m7G-capped U snRNA is exported to the cytoplasm. The m7G-cap is converted to m3G-cap, which is a hypermethylated structure of 5&rsquo;-end, by cytoplasmic catalytic protein TSG1 and the m3G-capped U snRNA forms snRNP with Sm proteins in the cytoplasm, followed by entry into the nucleus. The m3G-capped snRNP plays a role in regulation of pre-mRNA splicing as a part of spliceosome in nucleus. <a>It is also reported that</a>&nbsp; U3 and U8 snoRNA, localized to Cajal body during RNP biogenesis, possess m3G-cap structure.
Source / Host mouse
Storage -20°C
Substrate / Buffer 1 mg/mL in PBS/50% glycerol, pH 7.2

Shipping info

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Source/Host:

mouse mouse

Product insert:

Product data sheet

Datasheet

Suggested protocols:

Immunoprecipitation

Immunoprecipitation