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|Country Availability||SE, FI, DK, NO, IS, EE, LV, LT|
|Data Sheet Link||https://www.mblintl.com/assets/RN011M-v1.pdf|
|Description||Anti-2,2,7-trimethylguanosine (m<sub>3</sub>G/TMG) mAb|
|Supplier||MBL International Corp.|
|Immunogen||BSA-conjugated trimethylguanosine (m<sub>3</sub>G/TMG)|
|Notes||Small nuclear RNA (snRNA) is known to be involved in pre-mRNA splicing as an RNA component of snRNP. 2,2,7-trimethylated guanosine (m<sub>3</sub>G/TMG) is a modified nucleoside at the 5’-cap site of U snRNAs except for U6 snRNA. Shortly after transcription, 7-methylguanosine (m<sup>7</sup>G), called cap structure, is added to 5’-end of newly synthesized U snRNA and m<sup>7</sup>G-capped U snRNA is exported to the cytoplasm. The m<sup>7</sup>G-cap is converted to m<sub>3</sub>G-cap, which is a hypermethylated structure of 5’-end, by cytoplasmic catalytic protein TSG1 and the m<sub>3</sub>G-capped U snRNA forms snRNP with Sm proteins in the cytoplasm, followed by entry into the nucleus. The m<sub>3</sub>G-capped snRNP plays a role in regulation of pre-mRNA splicing as a part of spliceosome in nucleus. It is also reported that U3 and U8 snoRNA, localized to Cajal body during RNP biogenesis, possess m<sub>3</sub>G-cap structure.|
|References||1) Abreu, R. S., et al., J. Biol. Chem. E publication March 3, (2009) 2) Susaki, K., et al., Exp. Eye Res. 88, 347-355 (2009) 3) Kawahara, H., et al., J. Cell Biol. 181, 639-653 (2008) 4) Imai, T., et al., Mol. Cell Biol. 21, 3888-38900 (2001)|
|Source / Host||mouse|
|Substrate / Buffer||1 mg/mL in PBS/50% glycerol, pH 7.2|
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