Article No
PAT-Z8KDBS-100
MW | 50.2 kDa (456aa) confirmed by MALDI-TOF |
NCBI Number | NP_057870 |
Accession Number | NP_057870 |
Application | Electrophoresis |
Article No | PAT-Z8KDBS-100 |
Biosite Brand | Biosite Proteins |
Country Availability | all |
Concentration | 0.25 mg/ml |
Description | Recombinant mouse Adenosylhomocysteinase/AHCY protein |
Supplier | Nordic Biosite |
Entrez Gene ID | 11615,269378 |
Gene Symbol | Ahcy, Ahcyl |
Notes | Ahcy, also known as Adenosylhomocysteinase, is an enzyme that catalyzes the reversible hydrolysis of S-sdenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). AdoHcy hydrolysis is a reversible reaction with an equilibrium favoring AdoHcy formation, but hydrolysis prevails under physiological conditions due to the rapid removal of adenosine and homocysteine. Thus, AHCY s activity in mammals is directly related to homocysteine level, an independent risk factor for vascular disease. It also functions as a regulator of biological transmethylation by controlling the concentration of AdoHcy, a potent competitive inhibitor of all S-adenosyl-L-methionine methyltransferases. Recombinant mouse Ahcy, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
Alias Names | Adenosylhomocysteinase, AA987153, AL024110, CuBP, SAHH |
Previous Article No | PAT-Z8KDBS-100, Z8KDBS-100 |
Product Type | Enzymes |
Purity | >90% |
Sequence | MSDKLP YKVADIGLAA WGRKALDIAE NEMPGLMRMR EMYSASKPLK GARIAGCLHM TVETAVLIET LVALGAEVRW SSCNIFSTQD HAAAAIAKAG IPVFAWKGET DEEYLWCIEQ TLHFKDGPLN MILDDGGDLT NLIHTKYPQL LSGIRGISEE TTTGVHNLYK MMSNGILKVP AINVNDSVTK SKFDNLYGCR ESLIDGIKRA TDVMIAGKVA VVAGYGDVGK GCAQALRGFG ARVIITEIDP INALQAAMEG YEVTTMDEAC KEGNIFVTTT GCVDIILGRH FEQMKDDAIV CNIGHFDVEI DVKWLNENAV EKVNIKPQVD RYWLKNGRRI ILLAEGRLVN LGCAMGHPSF VMSNSFTNQV MAQIELWTHP DKYPVGVHFL PKKLDEAVAE AHLGKLNVKL TKLTEKQAQY LGMPINGPFK PDHYRY |
Size | 100ug |
Species Reactivity | mouse |
Storage | 4°C, -80°C |
Substrate / Buffer | Liquid. In 20mM Tris-Hcl buffer (pH8.0) containing 40% glycerol, 0.2M NaCl, 1mM DTT |
UniProt Number | P50247 |
Product Page Updated | 2024-03-18T08:02:54.462Z |