Article No
PAT-PQIAVX-100
Recombinant canine IL-21 protein
Recombinant canine IL-21 protein
Proteins & Peptides
Specifications
| MW | 15 kDa (130aa), confirmed by MALDI-TOF |
| Accession Number | NP_001003347.1 |
| Application | Electrophoresis |
| Article No | PAT-PQIAVX-100 |
| Biosite Brand | Biosite Proteins |
| Country Availability | all |
| Concentration | 0.5 mg/ml |
| Description | Recombinant canine IL-21 protein |
| Supplier | Nordic Biosite |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Entrez Gene ID | 442935 |
| Gene Symbol | IL21 |
| Notes | IL-21, also known as Interleukin-21, is an important modulator of natural killer (NK) cell function. However, little is known about IL-21 function in canine NK cells because the phenotype of these cells remains undefined. NK cells proliferated rapidly in response to activation by IL-21 for 3 weeks, and IL-21 was able to induce changes in the mRNA expression of NK cell-related receptors and enhance the effector function of NK cells in perforin- and granzyme-B-dependent manners. The duration, frequency and timing of IL-21 stimulation during culture affected the rate of proliferation, patterns of receptor expression, cytokine production, and anti-tumor activity. It has a potential predicating that synergistic interactions of IL-21 with IL-2 and IL-15 play an important role in the proliferation, receptor expression, and effector function of canine NK cells. Recombinant canine IL-21, was expressed in E. coli and purified by using conventional chromatography techniques. |
| Previous Article No | PAT-PQIAVX-100, PQIAVX-100 |
| Product Type | Proteins & Peptides |
| Purity | >95% |
| Sequence | MHKSSFQEQD LLLIRMRQLI DIVDQLKNYV NDLDPESLPA PEDVKRHCER SAFSCFQKVQ LKAANTGGNE QIINVLTKQL KRKLPPTNAG RRQKHRPACP SCDSYEKAPP KEFLERLKSL IQKMIHQHLS |
| Size | 100ug |
| Species Reactivity | dog/canine |
| Storage | 4°C, -80°C |
| UniProt Number | Q6L7I9 |
| Product Page Updated | 2024-04-17T08:28:29.021Z |